Development of a general methodology for labelling peptide–morpholino oligonucleotide conjugates using alkyne–azide click chemistry† †Electronic supplementary information (ESI) available: Experimental section and supplementary figures. See DOI: 10.1039/c3cc46067c Click here for additional data file.

Site-specific azide-acetyllysine photochemistry on epigenetic readers for interactome profiling† †Electronic supplementary information (ESI) available: Full experimental details, synthesis and characterizations of compounds, supplementary data, figures and references. See DOI: 10.1039/c7sc00284j Click here for additional data file. Click here for additional data file.

Synthesis of triazole-linked morpholino oligonucleotides via CuI catalysed cycloaddition† †Electronic supplementary information (ESI) available: Full experimental details and copies of 1H, 13C, 31P NMR spectra for all compounds. See DOI: 10.1039/c6ob00007j Click here for additional data file.

Triazole-linked morpholino ((TL)MO) oligonucleic acids were synthesised using the Cu(I) catalysed (3 + 2) azide-alkyne cycloaddition (CuAAC) reaction. The modified DNA analogues were incorporated into 13-mer sequences via solid phase synthesis. UV melting experiments showed that the (TL)MO modification gives higher Tm values than the corresponding (TL)DNA modification.

Systematic and site-specific analysis of N-sialoglycosylated proteins on the cell surface by integrating click chemistry and MS-based proteomics† †Electronic supplementary information (ESI) available: Supplementary text and references, six supplementary figures, and thirteen supplementary tables. See DOI: 10.1039/c5sc01124h Click here for additional data file. Click here for additional data file. Click here for additional data file. Click here for additional data file. Click here for additional data file. Click here for additional data file. Click here for additional data file. Click here for additional data file. Click here for additional data file. Click here for additional data file. Click here for additional data file. Click here for additional data file. Click here for additional data file. Click here for additional data file.

A complex stereochemical relay approach to the antimalarial alkaloid ocimicide A1. Evidence for a structural revision† †Electronic supplementary information (ESI) available: Supplementary schemes, figures, and tables, general experimental remarks, synthetic procedures, catalogues of experimental and calculated nuclear magnetic resonance spectra. CCDC 1536046. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c7sc01127j Click here for additional data file. Click here for additional data file.

Self-assembling α,γ-cyclic peptides that generate cavities with tunable properties† †Electronic supplementary information (ESI) available: Synthetic experimental details, DFT calculation details, additional figures (relevant NMR data) and schemes (synthetic schemes for peptide and amino acid preparation). CCDC 1400134. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c5sc03187g Click here for additional data file. Click here for additional data file.